This dataset contains major, trace, and volatile element contents, and sulfur isotope ratio data measured in silicate glasses found in volcanic rocks from the Central American Volcanic Arc. The files have been first published as supplementary data in: Taracsák et al. (2023): Sulfur from the subducted slab dominates the sulfur budget of the mantle wedge under volcanic arcs, Earth and Planetary Science Letters, 601:117948 The data is also accessable via the following DOI: https://doi.org/10.1016/j.epsl.2022.117948