The data set comprises rhenium isotope compositions, rhenium concentrations, total organic carbon concentrations, and titanium concentrations measured from bulk rock digestions of the Eagle Ford Shale in South Texas, USA. The samples were obtained from coeval strata recovered in drill core Innes-1 and outcrop sections DR5 and DR12. The project aimed to compare the isotopic composition of Re before and after oxidative weathering. Rhenium concentrations were measured by isotope dilution, using liquid-liquid (alcohol) extraction and measurement by MC-ICP-MS. Rhenium isotopes were measured after a 3-stage column purification procedure using MC-ICP-MS. MC-ICP-MS measurements were made with the addition of a tungsten spike to correct for instrumental mass fractionation. Total organic carbon concentrations were measured by Rock-Eval pyrolysis (Rock-Eval VI) and Ti concentrations by ICP-AES.