This dataset contains Leptospirosis case numbers for a number of place studies in Brazil, Malaysia, Philippines, Argentina, China and Sri Lanka. Leptospirosis case numbers are provided as weekly or monthly case numbers and cover the period 1978 to 2020, although timelines vary within place studies. Area-weighted daily average hydrometeorological variables are also included: precipitation, river discharge and soil moisture. The data have been collected and collated for a global analysis of the effect of hydrometeorological extremes on leptospirosis infection risk. Also included are the spatial polygons for each of the place studies.