Electron microprobe glass chemistry data from explosive eruption deposits from Popocatépetl, Iztaccíhuatl and Tláloc-Telapón volcanoes in Central México, spanning the last 700 ka. Associated with the following paper: Sunyé-Puchol, I., Hodgetts, A.G.E., Watt, S.F.L., Arce, J.L., Barfod, D.N., Mark, D.F., Sosa-Ceballos, G., Siebe, C., Dymock, R.C., Blaauw, M., Smith, V.C., 2021. Reconstructing the middle to late Pleistocene explosive eruption histories of Popocatépetl, Iztaccíhuatl and Tláloc-Telapón volcanoes in Central México. J Volcanol Geoth Res 421, 107413. https://doi.org/10.1016/j.jvolgeores.2021.107413