This dataset presents major (ICP-OES) and minor (ICP-MS) element data and fluid pH during interaction of simulated fracturing fluids with the Bowland-Hodder shale at a variety of conditions, i.e. fluid acidity (pH 1-5), temperature (25-70 C), and rock/fluid ratio (from 0.2:200 to 20:200), as well as two end member mineralogical compositions (from 618 m depth and 673 m depth). The data was collected under the SECURe (Subsurface Evaluation of CCS and Unconventional Risks funded under the European Union’s Horizon 2020 research and innovation programme under grant agreement number 764531. Data supplied by permission of University of Nottingham and British Geological Survey.